factor xii
Definition
- Noun:
- A coagulation factor: Factor XII is a specific protein present in blood plasma that plays a role in the coagulation cascade, which is the process by which blood clots.
- A substance whose deficiency causes a specific condition: A deficiency or lack of Factor XII in the blood results in a prolonged clotting time for venous blood, meaning it takes longer than normal for a clot to form.
Usage Examples
- Noun:
- The doctor ordered a test to check the patient's Factor XII levels.
- Hereditary deficiency of Factor XII is a rare condition.
- Factor XII is also known as Hageman factor.
Advanced Usage
- In medical diagnostics: The term is used to describe a specific lab finding or a component of a coagulation panel.
- The prolonged activated partial thromboplastin time (aPTT) was investigated and found to be due to Factor XII deficiency.
- In research contexts: Often discussed in studies of blood coagulation pathways and disorders.
- The study examined the role of Factor XII in thrombosis.
Variants and Related Words
- Hageman factor: Another name for Factor XII.
- Coagulation factor: The general category to which Factor XII belongs. Other examples include Factor VIII and Factor IX.
- Factor XII deficiency: The medical condition resulting from insufficient levels of this protein.
Synonyms
- Hageman factor: This is a direct synonym, named after the first patient diagnosed with its deficiency.
- Plasma thromboplastin antecedent (PTA): An older, less common synonym.
Related Phrases
- Contact activation pathway: The intrinsic pathway of coagulation, which Factor XII helps initiate.
- Prolonged clotting time: A key clinical effect of Factor XII deficiency.
Noun
-
coagulation factor whose deficiency results in prolongation of clotting time of venous blood
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